![]() Taken together, because HIV is associated with chronic The hippocampus ( Yaffe, Falvey, & Hoang,Ģ014). Neurodegeneration through increased neuroinflammation and disrupted neurogenesis in Supporting proper glymphatic function to clear neurotoxins from the brain ( Eugene & Masiak, 2015 Fultz et al., 2019), and poor sleep may contribute to Moreover, it is hypothesized that sleep may promote cognition by Patients with Alzheimer’s disease (i.e., increased sleep fragmentation,Īrousal deficiencies Oh et al., 2019 Peter-Derex, Yammine, Bastuji, & Croisile,Ģ015). Which has been hypothesized to account for the sleep-wake disruption seen in (i.e., p-tau) has also been shown to target wake-promoting neurons in the brain, Neurodegenerative disorders (e.g., Alzheimer’s disease Crowley, 2011). Geriatric literature, studies suggest sleep quality decreases as a result of normalĪging and more profound sleep disturbances are associated with age-related ![]() ![]() Medications, and psychosocial variables (e.g., depression, stress Allavena et al., 2016 Gallego et al., 2004 Vosvick et al., Neurotoxic cascade initiated by HIV (e.g., inflammation), antiretroviral PWH, sleep disturbance is hypothesized to be a multidetermined result of the HIV-negative adults (14–38% Morin, LeBlanc,ĭaley, Gregoire, & Merette, 2006 Ohayon, 2002) in comparison to the general population (10% Ram, Seirawan, Kumar, & Clark, 2010). The prevalence of sleep disturbance is elevated in both PWH (58% Wu, Wu, Lu, Guo, & Li, 2015) and older Potentially modifiable health-related behaviors that may promote successful Need to identify predictive markers of neurocognitive impairment and investigate Therefore, as the population of older PWH continues to grow, there is an important Preserved cogntion and everyday functioning Malaspina et al., 2011 Moore et al., PWH are able to achieve successful cognitive aging (i.e., generally defined as However, recent studies demonstrate that some Remains prevalent among PWH, particularly in PWH aged 50 and older ( Cherner et al., 2004 Makinson et al., 2019). ![]() Despite theīeneficial effects of cART on controlling HIV viremia, neurocognitive impairment Improved life expectancy among persons with HIV (PWH) who have access to adequate The availability of combination antiretroviral therapy (cART) has greatly ![]()
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